COP9 signalosome: Discovery, conservation, activity, and function
نویسندگان
چکیده
منابع مشابه
The COP9 signalosome
But what does it really do? This is the $64,000 question. If we must join in the rampant speculation, the CSN probably has multiple functions. It may serve as a master dock, bringing together proteins, such as a kinase, its substrate, and the proteasome. The CSN might even be an alternative or additional proteasome lid, shuttling ubiquitinated substrates from the SCF to the proteasome. Alternat...
متن کاملThe COP9 signalosome.
The COP9 signalosome (CSN) is composed of eight distinct subunits and is highly homologous to the lid sub-complex of the 26S proteasome. CSN was initially defined as a repressor of photomorphogenesis in Arabidopsis, and it has now been found to participate in diverse cellular and developmental processes in various eukaryotic organisms. Recently, CSN was revealed to have a metalloprotease activi...
متن کاملThe COP9 signalosome and vascular function: intriguing possibilities?
Disorders of vascular function contribute importantly to cardiovascular disease which represents a substantial cause of morbidity and mortality worldwide. An emerging paradigm in the study of cardiovascular diseases is that protein ubiquitination and turnover represent key pathological mechanisms. Our understanding of these processes in the vasculature is growing but remains incomplete. Since p...
متن کاملCOP9 signalosome regulates autophagosome maturation.
BACKGROUND Autophagy is essential to intracellular homeostasis and is involved in the pathophysiology of a variety of diseases. Mechanisms regulating selective autophagy remain poorly understood. The COP9 signalosome (CSN) is a conserved protein complex consisting of 8 subunits (CSN1 through CSN8), and is known to regulate the ubiquitin-proteasome system. However, it is unknown whether CSN play...
متن کاملMycobacterium tuberculosis Alters the Metalloprotease Activity of the COP9 Signalosome
Inhibition of apoptotic death of macrophages by Mycobacterium tuberculosis represents an important mechanism of virulence that results in pathogen survival both in vitro and in vivo. To identify M. tuberculosis virulence determinants involved in the modulation of apoptosis, we previously screened a transposon bank of mutants in human macrophages, and an M. tuberculosis clone with a nonfunctiona...
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ژورنال
عنوان ژورنال: Journal of Integrative Plant Biology
سال: 2020
ISSN: 1672-9072,1744-7909
DOI: 10.1111/jipb.12903